Retatrutide is going to help you massively in getting you to that ideal 10% bodyfat to get them facial bones to pop out your face. It is also going to help you in managing and maintaining bodyfat. Having bones covered in fat is absolutely fucking useless. Here will be a full breakdown of Retatrutide, and why you should be using it over the other GLP-1 agonists like Semaglutide and Tirzepatide.
Mechanism of action
Retatutuide is a triple agonist, which means that it works on three receptors, namely the GLP-1 receptor, GIP receptor and Glucagon.
GLP-1 Agonist
All 3 of these drugs are going to work on the GLP-1 receptor and is the cornerstone of its appetite suppression and metabolic benefits. The agonism of the GLP-1 receptor is going to increase hunger control and appetite suppression. It is also going to have an effect on gastric emptying. This means it is going to slow down digestion to prolong the satiety of a meal, which results in reducing meal frequency. Slower gastric emptying will also reduce post-meal glucose spikes, and will decrease demand on insulin secretion. So if you are getting fuller quicker and staying full for longer, you are going to be able to eat less and be in a calorie deficit effortlessly. GLP-1 agonism is also going to help improve insulin sensitivity as it enhances glucose dependent secretion. Mono-agonists (semaglutide) are absolutely the worst in regards to side effects because it doesn't have the anti-emetic component of Reta/Tirz.
GIP Agonist
Unlike Semaglutide, Tirzepatide and Retatrutide also affect the GIP receptor. Retatrutide has the strongest affinity at GIP receptors than any of the GLP-1 agonists, it's primarily a GIP agonist. With the GIPR agonism, you get an array of benefits that obviously mono-agonists (Sema) don't produce. GIPR is highly synergistic with GLP1R. First off, it has an anti-emetic/anti-nausea effect, which explains why people experience less side effects when using Tirzepatide and Retatrutide in comparison to Semaglutide. Most of its action occurs within the pancreas, brain and adipose tissue. Dual agonism will enhance satiety signalling in the brain, again helping decrease that “calories in” portion. The GIPR seems to be highly active within adipose tissue, majorly increasing insulin sensitivity, increasing blood flow to adipocytes, decreasing pro-inflammatory adipokines whilst simultaneously increasing anti-inflammatory ones (adiponectin). GIPR also helps improve nutrient partitioning since it enhances lipid oxidation in skeletal muscle which results in less muscle loss, at least in comparison to Semaglutide which doesn’t have an effect on the GIP receptor. Tirz has a weaker affinity for GIPR than Retatrutide and it isn't even a full agonist (partial agonist).
Glucagon Agonist
The glucagon agonist is what differentiates Retatrutide from all Sema/Tirz and is retatrutide’s secret weapon, if you will. Glucagon increases heart rate and cardiac output/contractility, and lowers pulmonary vascular resistance. Like GLP-1, it also increases satiety, slows gastric emptying, and changes our appetite preferences. Most importantly, glucagon has a multitude of effects on the liver and brown and white adipose tissue (aka fat). In the liver it increases liver cell survival and increases lipolysis which creates free fatty acids, which our body then turns into ketones for energy. In fat cells it increases thermogenesis and lipolysis which further drives that free fatty acids to ketone bodies cycle. It’s literally forcing your body to burn excess fat. Most studies will tell you this effect is probably in the neighbourhood of an extra 150-200 calories of excess energy expenditure per day. This will help increase the “calories out” portion.
Summary of Retatrutide benefits
- Decreased apatite
- Decreased eating frequency
- Improves insulin sensitivity
- Suppresses glucagon (lowers blood sugar)
- Improves nutrient partitioning (less muscle loss)
- Enhances fat metabolism
- Boosts insulin secretion
- Increases resting energy expenditure
- Boosts fat oxidation
- Eliminates visceral fat
Retatrutide dosage protocol
If you have not used GLP-1 Agonists before start with a dosage of 2.5mg and titrate up to 5mg if you are side effect free. Ideally work up to a dosage of 7.5-10mg per week.